Disulfram (Antabuse®)
- primarily works by inhibiting the action of an enzyme involved in the metabolism of alcohol – the conversion of acetaldehyde to acetate
- this inhibition leads to accumulation of acetaldehyde following consumption of alcohol, the resulting unpleasant symptoms – flushing, dizziness, nausea and vomiting, irregular heartbeat, breathlessness and headache – are due to the toxicity of accumulated acetaldehyde
- acts as a deterrent to drinking because the individual expects to experience these negative consequences
- appears to be most effective when the medication is provided to the individual under supervision
Treatment Availability
Indications (when treatment might be suitable)
Contraindications (when treatment will not be suitable)
Effects & mechanism of action
Potential side effects & risks (including overdose)
Ceasing or withdrawing from treatment
Further Resources
